Tylenol (Acetaminophen) & Motrin (Ibuprofen) Dosing Guide: W

Key Differences Between Tylenol & Motrin

Tylenol (Acetaminophen):

  • Used for fever and pain relief (e.g., headaches, general discomfort).
  • Can be used over the counter in age 3 months and older
  • Check with your medical provider for use in under 3 months
  • Does not reduce inflammation.

Motrin (Ibuprofen):

  • Used for fever, pain, and inflammation (e.g., ear infections, sore throat).
  • Only for infants 6 months and older.
  • Consider avoiding if the child has stomach upset, a bleeding risk or kidney disease

Understanding Medication Names

What's the difference between brand-name and generic medicines?

Brand-name medicines (like Tylenol® or Motrin®):

  • Created by pharmaceutical companies that developed the medicine
  • Have trademarked names protected by law
  • Are typically more expensive because of research and marketing costs
  • Contain the same active ingredients as their generic versions

Generic medicines (Acetaminophen, Ibuprofen):

  • Contain the exact same active medicine 
  • Are sold under the medicine's official name (not a brand name)
  • Are required by law to work exactly the same way
  • Cost 30-80% less than brand names

Examples you might see at the store:

  • Instead of Tylenol® → "Acetaminophen" (with store name like "CVS Health" or "Equate")
  • Instead of Motrin® → "Ibuprofen" (with pharmacy branding)

How to Measure a Temperature

Key Points for Accurate Temperature Measurement:

  • For infants < 3 months: Prefer rectal temperature (most accurate for this age).
  • For older children & adults: Oral temperature is preferred if possible.
  • Temporal (forehead) thermometers: Should measure core temperature but can be inconsistent. Verify readings by taking multiple measurements or checking on another person.
  • Tympanic (ear): use in age 2 years or older, excessive ear wax can cause temperature discrepancies 
  • Axillary (underarm) temperature: Least accurate—use only if no other method is available.

Types of Temperature Measurements

  • Core Temperature (Most Accurate for Fever Detection):
    • Includes rectal, oral, and temporal (forehead) readings.
  • Tympanic (ear) Temperature: 
    • Can be used in children 2 years and older
  • Axillary (Underarm) Temperature:
    • Least accurate method.
    • Not considered a core temperature—use only if no other option is available.

What Counts as a True Fever?

  • A true fever is a core temperature (rectal, oral, or temporal) of 100.4°F (38°C) or higher.
  • For detailed temperature-taking guidelines by age for fevers, refer to the chart below.

Dosing by Weight/Age

⚠️ Always use the syringe or dosing cup provided—never household spoons. Use weight before age information to dose.

Acetaminophen (Tylenol) Dosing

Charts of Tylenol (Acetaminophen) Dosing by Weight and Age, for Liquid and Tablet Medication Types

Motrin (Ibuprofen) Dosing

Chart of Motrin (Ibuprofin) Dosing by Weight and Age

Critical Safety Information

⚠️ Before giving medication:

  • Check that no other medicines contain acetaminophen or ibuprofen (e.g., some cold medicines)—this may lead to overdosing.
  • Confirm the concentration (mg/mL) on the bottle—some infant drops differ from children’s liquid.

When to Contact Poppins

  • To help you figure out the exact weight based and safe dosing of Tylenol or Motrin for your child
  • If you have questions about your child’s sick symptoms. 

When to Contact Your Pediatrician

  • Fever ≥104°F that does not improve with medication.
  • Fever that lasts >3 days
  • Fever ≥100.4°F in an infant 2-3 months old
  • Pain that lasts >5 days or is worsening

When to go to the ER 

  • Fever ≥100.4°F in a baby 2 months or younger

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